Chronic, non-healing wounds including diabetic foot ulcers, pressure ulcers, and leg ulcers can be a source of pain and discomfort in the patients, adversely affecting their quality of life. Therefore, the management of such wounds has become one of the major medical challenges.
Inflammation is a pathophysiological aspect in various chronic diseases including rheumatoid arthritis, diabetic nephropathy, and Crohn’s disease. These immune-mediated or inflammatory disorders not only result in decreased quality of life but may also lead to deformity, or non-reversible organ/tissue damage.
Degenerative joint disorders including osteoarthritis and rheumatoid arthritis affect millions of people worldwide and may lead to chronic pain, disability, immobility, and difficulty in carrying out daily activities. Delayed disease progression and joint replacement may offer some help in such conditions.