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BabyShield takes pride in introducing the First Trimester Penta Marker Screening, the most advanced technology to screen early pregnancies and rule out chromosomal defects (Trisomy 13, 18, 21) in fetuses. Penta Marker screening otherwise known Expanded First Trimester Screening analyses 5 serum markers in the maternal blood sample to detect Chromosomal Trisomies and Pre-eclampsia.


The conventional first trimester testing uses the double marker for detection of Trisomies 13, 18 and 21, for the past 20 years. To enhance the Detection Rate and reduce the False Positive Rate to bare minimum, BabyShield introduces its fresh initiative of the expanded first trimester screening. Penta Marker screening incorporates biochemical screening technique with more protein markers in addition to dual marker. It is offered to all patients for its ability to forecast adverse outcomes of pregnancy, early. It also has the potency to reduce the need for further invasive testing to the least due to its precision in terms of better Detection Rate and lower False Positive Rate.

Markers Analysed in Penta Marker Screening

There are 5 maternal serum that are analysed in the "Penta Marker Screening" during the first trimester.

5 benefits

Benefits Of Penta Marker Screening

  • In Detection Of Down Syndrome - For Trisomy 21, at a 1/300 risk cut-off, the Detection Rate of screening with the Penta Marker along with n & t and nasal bone is 98% and the False Positive Rate is as low as 1.2%. Using 1/1000 cut-off the Detection Rate is as high as 99% and the False Positive Rate is 2.6%.
  • In Detection of Edward & Patau Syndrome - For Trisomy 18/13 with free Beta Human Chorionic Gonadotropin, pregnancy-associated Plasma Protein A, Placental Growth factor and n & t at a 1/150 cut-off, Detection Rate was 95% and the False Positive Rate was 0.5%, while at a 1/500 risk cut-off, Detection Rate was 97% and the False Positive Rate was 1.2%.
  • Penta Marker reduces the incidence of subjecting mothers to go for high risk invasive testing procedures or to go for an expensive NIPT test.
  • This screening fits well with proposed contingency protocol as a secondary test, by providing advantages such as identification of high risk pregnancies with early-onset Pre-eclampsia.