Community Banking Brochure(EPIP)

  1. Stem cells applications have been performed for over 50 years with over 13 lakh transplants. 

    Gratwohl A, Pasquini MC, Aljurf M, Atsuta Y, Baldomero H, Foeken L, Gratwohl M, Bouzas LF, Confer D, Frauendorfer K, Gluckman E, et. al. One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol. 2015; 2(3):e91–e100.

  2. More than 50,000 stem cell transplants are performed annually worldwide.

    http://www.who.int/transplantation/hsctx/en//

  3. Umbilical cord blood stem cells can treat over 80 medical conditions.

    https://www.asbmt.org/patient-education/terms-and-definitions

  4. Umbilical cord blood stem cells can treat over 80 medical conditions.

    https://parentsguidecordblood.org/en/diseases

  5. 500+ stem cell clinical trials worldwide.

    https://clinicaltrials.gov/ct2/results?term=umbilical+cord+blood&Search=Search

  6. 1 in 217 may undergo stem cell transplant by age of 70 years.

    Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM. Lifetime probabilities of hematopoietic stem cell transplantation in the US. Biol Blood Marrow Transplant. 2008;14(3):316–322.

  7. Cord blood stem cells used for over 30 years in more than 50,000+ transplants across the world.

    Dessels C, Alessandrini M, Pepper, MS. Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape. Stem Cells Transl Med. April 2018.

  8. 90% medical conditions require stem cells from a healthy matching donor and not own stem cells.70% Indian patients do not find a matching donor in their own family.An adult may require two cord blood units for stem cell transplants.Consensus Statement of Indian Academy of Pediatrics (IAP) - 15th June, 2018.LifeCell’s Community Banking aligns with recommendations of medical bodies in India and abroad.

    Sachdeva A, Gunasekaran V, Malhotra P, Bhurani D, Yadav SP, Radhakrishnan N, Kalra M, Bhat S, Misra R, Jog P. Umbilical Cord Blood Banking: Consensus Statement of the Indian Academy of Pediatrics. Indian Pediatrics, Vol 55, June 15, 2018

  9. Stem cell transplant matching (HLA typing) requires 4 to 6 parameters match between a patient and donor. <>The most successful transplant happen when the patient’s HLA and donor HLA closely match. Siblings have 25% chance of being a full match.

    https://bethematch.org/for-patients-and-families/finding-a-donor/hla-matching/

  10. Matching with own baby is difficult for any of the parents.

    http://www.pedsoncologyeducation.com/BMTHLATyping2.asp

  11. 6500 donor cord blood samples in largest public cord blood bank in India. Jeevan public cord blood bank based in India is the largest in Southeast Asia and has stopped accepting further samples due to lack of funds.<>HLA matching is ethnicity dependent and the chance of an Indian finding a match from these global public cord blood banks is less than 10%. <>Cost of procurement of one cord blood unit from abroad is ~INR 30 lakhs.

    http://www.jeevan.org/stem-cell-bank/

  12. 750,000 cord blood units are currently available at 55 major public banks in the world.

    https://statistics.wmda.info/

  13. Cost of procurement of one cord blood unit in India is ~ INR 15-20 lakhs. <>The hospital treatment cost for stem cells transplant in India might accrue to ~INR 15 to 20 lakhs.

    Sharma SK, Choudhary D, Gupta N, Dhamija M, Khandelwal V, Kharya G, Handoo A, Setia R, Arora A. Cost of Hematopoietic Stem Cell Transplantation in India. Mediterr J Hematol Infect Dis. 2014; 6(1): e2014046

  14. As per WHO, India has the third highest number of blood cancer patients in the world after the US and China.

    https://scroll.in/article/739401/it-isnt-just-the-disease-that-kills-most-blood-cancer-patients-in-india-its-the-wait

  15. Every 9 minutes, someone in the USA dies from blood cancer.<>Every 3 minutes, one person in the USA is diagnosed with blood cancer.

    https://www.lls.org/http%3A/llsorg.prod.acquia-sites.com/facts-and-statistics/facts-and-statistics-overview/facts-and-statistics

  16. In India, about 3 children per 1000 live births are diagnosed with Cerebral Palsy.

    Das SP, Ganesh GS. Evidence-based Approach to Physical Therapy in Cerebral Palsy. Indian J Orthop. 2019; 53(1):20–34.

  17. In India, about 1 in 100 children are diagnosed with Autism under the age of 10 years.

    Arora NK, Nair MKC, Gulati S, Deshmukh V, Mohapatra A, Mishra D, et al. Neurodevelopmental disorders in children aged 2-9 years: population-based burden estimates across five regions in India. PLoS Med. 2018;15(7):e1002615.

  18. In India, Although 1 Lakh New Blood Cancer Cases Are Diagnosed Annually, Only About 2000 Stem Cell Transplants Are Done Every Year.

    https://www.deccanherald.com/amp/opinion/panorama/need-for-indians-to-donate-stem-cells-725101.html

  19. An ICMR study says that a bank with over 25,000 donated cord blood samples provides 96% chance of finding a matching unit for an Indian.

    Maiers M, Halagan M, Joshi S, et al. HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study. Lancet Haematol. 2014;1:e57–63

  20. In the majority of blood disorders, the child’s own stored cord blood cannot be used for the same child as they will carry the same genetic defect - Padma Shri Dr. K. K. Aggrawal, Immediate Past President of Indian Medical Association (IMA)

    http://www.indialegallive.com/top-news-of-the-day/analysis-updates/drugs-cosmetics-act-stem-cells-drug-47659

  21. Community cord blood banking is the perfect solution to bring technological capability to the masses - leveraging India’s high birth rate to bring life changing treatment available to patients who have life-threatening illnesses - Dr. Purvish Parikh, Director, Precision Oncology and Research, Asian Institute of Oncology, Somaiya Ayurvihar Cancer Care Molecular Oncology Society - May 2017.

    https://www.deccanherald.com/content/609865/saving-lives-through-umbilical-cord.htm

  22. Cord blood transplants in India has been very low mainly due to high cost and limited number of units available. With more than 25,000 cord blood units, the bank shall be able to provide a matched cord blood for 96% of its patients - Dr Rahul Bhargava, Director and Head, Hematology and Bone Marrow Transplant, Fortis Memorial Research Institute, Gurgaon.Current NEED is at least 50,000 Cord Blood Transplants every year in India.

    http://indiacsr.in/india-in-desperate-need-of-a-public-cord-blood-bank/

  23. American Congress of Obstetricians and Gynecologists (ACOG) Committee Opinion on Cord Blood Banking.

    https://www.acog.org/-/media/Committee-Opinions/Committee-on-Genetics/co648.pdf

  24. American Academy of Pediatrics (AAP) recommendations on Cord Blood Banking.

    https://doi.org/10.1542/peds.2017-2695

  25. American Society for Blood and Marrow Transplantation (ASBMT) Report on Collection and Preservation of Cord Blood for Personal Use.

    https://higherlogicdownload.s3.amazonaws.com/ASBMT/43a1f41f-55cb-4c97-9e78-c03e867db505/UploadedImages/ASBMT_Committee_Report_Collection_and_Preservation_of_Cord_Blood_for_Personal_Use.pdf

  26. Eligibility Criteria For Cord Blood Specimen to Qualify for Listing In LifeCell Registry.

    https://www.fda.gov/regulatory-information/search-fda-guidance-documents/bla-minimally-manipulated-unrelated-allogeneic-placentalumbilical-cord-blood-intended-hematopoietic

  27. Assessment of Hetastarch and PrepaCyte-CB® in Transplanted Cord Blood Units. Poster presented at: ICBS 2017. 15th Annual International Cord Blood Symposium; 2017; San Diego, California.

    https://www.cryo-cell.com/CryoCell/media/CryoCell/Documents-Forms/assessment-of-hetastarch-prepacyte-transplanted-cord-blood-units.pdf

  28. Sepax / Sepax 2 Days To Recovery - 20 Days

    https://www.fda.gov/media/84567/download

    https://www.fda.gov/downloads/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/UCM483861.pdf

    https://www.fda.gov/downloads/BiologicsBloodVaccines/CellularGeneTherapyProducts/ApprovedProducts/UCM305761.pdf

  29. AXP / AXP II Days To Recovery - 21 Days

    https://www.fda.gov/media/84567/download

  30. TNCC Recovery For PrepaCyte-CB® is 85-90%

    Akel, S., Murray, C., Ferguson, W. and Babic, A. Outcomes of processing of bone marrow harvests for hematopoietic stem cell transplantation in pediatric patients utilizing a novel red blood cell sedimentation kit. Transfusion, 59: 2375-2381. (2019)

  31. TNCC Recovery For Sepax / Sepax 2 is 75-80%

    Alcaina, P. Solves, V. Mirabet, D. Planelles, A. Blanquer, L. Larrea, and R. Roig. "Comparison between Two Automatic Devices for Cord Blood Volume Reduction." 37th Annual Meeting of the European Group for Blood and Marrow Transplantation (EBMT), Paris, France, Apr. 2011.

  32. TNCC Recovery For Sepax / Sepax 2 is 75-80%

    Basford C, Forraz N, Habibollah S, Hanger K, McGuckin C. The cord blood separation league table: a comparison of the major clinical grade harvesting techniques for cord blood stem cells. International Journal Stem Cells. 2010 May; 3(1):32-45.

  33. TNCC Recovery For Sepax / Sepax 2 is 75-80%

    Collection, Processing, and Banking of Umbilical Cord Blood Stem Cells for Clinical Use in Transplantation and Regenerative Medicine: David T. Harris, MS Badowski, Department of Immunobiology, University of Arizona, Tucson, AZ, USA (2012).

  34. TNCC Recovery For Sepax / Sepax 2 is 75-80%

    Umbilical Cord Blood Processing Analysis: Comparison of Methodologies: M. Fisk, N. D. Kalmin, C. Cielak, R. Adams, T. Traylor; Texas Cord Blood Bank, San Antonio, TX (2008).

  35. TNCC Recovery For Sepax / Sepax 2 is 75-80%

    http://www.omniamed.net/upload/CONF19/20121210/sepax_brochure.pdf

  36. RBC Depletion by PrepaCyte-CB® is 99%

    https://www.businesswire.com/news/home/20070509005094/en/Clinical-Study-Finds-BioEs-PrepaCyte-CB-Significantly-Improves

  37. RBC Depletion by Sepax / Sepax 2 is 84.70%RBC Depletion by AXP / AXP II is 70%

    https://www.cryo-cell.com/difference/processing-technology

  38. Why red blood cells (RBCs) should be removed before cord blood storage?

    https://parentsguidecordblood.org/en/news/why-red-blood-cells-should-be-removed-cord-blood-storage

  39. Data based on websites of DCGI licensed Indian cord blood banks and Client Agreement.

  40. MSC’s are a type of stem cells that have the potential to differentiate into bones, cartilages and muscles.

    Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop DJ, Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 2006;8:315–317.

  41. MSC’s are considered to be ‘universal donor cells’ that do not need donor-recipient matching.

    Atoui R., Chiu R.C. Mesenchymal stromal cells as universal donor cells. 2012 Exp. Opin. Biol. Ther. 2012;12:1293–1297

  42. In India, a biotech company has already received the DCGI approval to market such an expanded MSC’s product developed from donated adult human bone marrow for treatment of Critical Limb Ischemia (CLI) due to Buerger’s Disease.Provide DCGI approved expanded MSC’s product derived from donated adult human bone marrow for immediate access.

    http://www.stempeutics.com/stempeucel.html

  43. Commercial banking of baby’s own cord tissue is not licensed and is prohibited in India, to prevent exploitation of parents by banks who charge huge fees.

    http://dbtindia.gov.in/regulations-guidelines/guidelines/national-guidelines-stem-cell-research-%E2%80%93-2017

  44. National Apex Committee for Stem Cell Research and Therapy (NAC-SCRT) approved MSC’s from donated human cord tissue in future (subject to government regulations).

    http://bic.icmr.org.in/nacscrt/

  45. In fact, almost all the current active human clinical trials related to umbilical cord tissue are using MSC’s obtained from donated sources.

    https://parentsguidecordblood.org/en/diseases

    https://parentsguidecordblood.org/en/trials-umbilical-cord-tissue

  46. Banks can only store stem cells derived from cord blood. Anyone offering to store stem cells derived from any other sources is indulging in unethical medical practice.” - Dr. Geeta Jotwani (ICMR)

    https://scroll.in/article/print/855553

  47. When treating blood related medical conditions, the stem cells transplant dose should be at least 25 million TNC per kilogram of patient body weight.

    https://parentsguidecordblood.org/en/faqs/how-much-cord-blood-is-needed-for-a-transplant

Community Banking Flyer

  1. Umbilical cord blood stem cells can treat over 80 medical conditions.

    https://www.asbmt.org/patient-education/terms-and-definitions

    https://parentsguidecordblood.org/en/diseases

  2. Stem cells applications have been performed for over 50 years with over 13 lakh transplants.

    Gratwohl A, Pasquini MC, Aljurf M, Atsuta Y, Baldomero H, Foeken L, Gratwohl M, Bouzas LF, Confer D, Frauendorfer K, Gluckman E, et. al. One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol. 2015; 2(3):e91–e100.

  3. Cost of procurement of one cord blood unit in India is ~ INR 15-20 lakhs.

    Sharma SK, Choudhary D, Gupta N, Dhamija M, Khandelwal V, Kharya G, Handoo A, Setia R, Arora A. Cost of Hematopoietic Stem Cell Transplantation in India. Mediterr J Hematol Infect Dis. 2014; 6(1): e2014046

  4. 90% medical conditions require stem cells from a healthy matching donor and not own stem cells.70% Indian patients do not find a matching donor in their own family.

    Sachdeva A, Gunasekaran V, Malhotra P, Bhurani D, Yadav SP, Radhakrishnan N, Kalra M, Bhat S, Misra R, Jog P. Umbilical Cord Blood Banking: Consensus Statement of the Indian Academy of Pediatrics. Indian Pediatrics, Vol 55, June 15, 2018