Source and Uses of Stem Cells | LifeCell

Uses of Stem Cells

Our Need For Stem Cells

Probability Of Being Diagnosed of a condition treatable by stem cells

Every individual has a 5% probability of being diagnosed with a condition treatable by stem cells. Hence for a family of 8 members that includes the child, siblings, parents and grandparents,there is a high probability of 40% for the family members to be diagnosed with a condition that requires stem cells for its treatment.

Where are these stem cells found?

Stem cells are found and retrieved from various parts of the body such as the peripheral blood, bone marrow and the umbilical cord.
Amongst these sources, Umbilical cord blood is considered to be a ready source of stem cells and can be preserved at birth and used for treatments when required. Stem cells extracted from cord blood are used efficiently in the treatment of blood-related conditions such as Thalassemia, Leukemia, Lymphoma, Neuroblastoma and so on. Cord blood stem cells have been used for over 25 years in 35000+ transplants across the world.

Why do we need stem cells from a donor?

However, majority (>90%) of the conditions would require matching stem cells from a healthy donor for treatment as our stem cells lack the innate capability to resolve the problem. Transplant matching (also known as HLA typing) requires 8-10 parameters to be common between a patient and donor, and hence odds of finding a match is significantly lesser than finding for example a matching blood unit for transfusion.

Current options available to source own and donor stem cells

Matching stem cells can be procured from a ‘Public Stem Cell Bank’ where frozen umbilical cord blood stem cells from unrelated donors are available at a cost. The other source is obtaining matching stem cells from a registered voluntary donor listed in a ‘Marrow Donor Registry’. However, both these sources have their own challenges in finding matching stem cells when required.
Marrow Donor Registry
Public Stem Cell Bank

Challenges of sourcing a matching donor from the above options

Marrow Donor Registry:

The listing of voluntary bone marrow donors in Indian registries is very low (<1% of global donor base despite India accounting for 20% of world population) leading to very low probability of finding matching stem cells of Indian ethnicity.

Further 40-50%16 of the registered donors could also be unavailable or refuse to donate his stem cells, when required for transplant. Even if available there could also be a delay20 in donor’s providing stem cells due to their prior commitments.

Public Stem Cell Bank:

Indian cord blood registries collectively have only ~5,00017 units preserved whereas an estimated 2,50,00018 units are required for >90% probability of finding a match.

Further to recover their investments these public banks charge a fee of 15-2019 Lakhs per unit

The Need
An ideal solution wherein a large inventory of stem cells of Indian origin are available immediately when required for transplant at a low cost.
The Comprehensive Solution has arrived EXPLORE