Chromosomal MicroArray (CMA)

A high-resolution cytogenetic tool to assess microlevel changes in the chromosome

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Chromosomal MicroArray (CMA) Overview

The genetic material of humans is packed into small units called chromosomes that have their own genetic combinations. The slightest change in the genetic combination of these chromosomes– either addition, deletion, or an exchange – can result in birth defects, developmental delays, autism, and other health issues. The Chromosomal MicroArray is a high-resolution molecular genetic test that screens for such varied chromosomal DNA changes that may otherwise go undetected

When is the test recommended?

CMA testing is often recommended in the following scenarios:

  1. Multiple abnormalities which are not specific to a genetic syndrome
  2. Non-syndromic developmental delay or intellectual disability
  3. Autism Spectrum Disorders

Chromosomal MicroArray helps prospective parents in more ways than one

Provides a confirmed diagnosis for a series of chromosomal defect

Allows you to begin planning for a child with special needs or make a decision about carrying the child to term.

Offers results in up to 10 days.

Provides Genetic Counselling after the test to understand your results better.

How Does Chromosomal MicroArray Work?

Booking The Test

Your doctor places an order for the test.

Collection

Requires POC as a sample.

Laboratory Analysis

Testing and analysis is done in the lab.

Reports

The results are shared within 10 business days.

Counselling

Post-result counselling is offered to parents to understand the reasons behind the pregnancy loss and cope better.

Begin your healthy pregnancy journey with

Chromosomal MicroArray

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Please note that Chromosomal MicroArray can only be ordered by a physician. They would also be the only person to receive your results and will pass them along to you. If you are unable to find a physician, contact us on 1800-266-5533 & we will organise one for you at no additional cost.

Frequently Asked Questions

  1. If maternal blood tests during pregnancy were abnormal, indicating an increased chance of a medical anomaly or birth defect.
  2. If an anomaly was detected on ultrasound.
  3. If the mother already has a child with birth defects such as chromosomal changes.
  4. In the case of Recurrent Pregnancy Loss.
  5. In case of advanced maternal age.
  1. Identifies microdeletion/microduplication syndromes not detectable through karyotyping
  2. Simultaneously detects maternal cell contamination on direct microarray analysis of amniotic fluid or chorionic villi without the need for a maternal blood sample
  3. Allows for more precise medical management and genetic counselling

Sample for the test can be obtained using the following methods:

  1. Chorionic villus sampling (CVS). - This includes obtaining a small sample of the baby’s cells from the chorionic villi, which are placental tissues.
  2. Amniocentesis - This includes obtaining a sample of the amniotic fluid, or the liquid that surrounds your baby in the womb.
  3. Genomic DNA.
  4. Cordocentesis: A method used to collect a sample of the fetus's blood from the umbilical cord for further testing.
  1. Highly sensitive test with >99% sensitivity detection for chromosomal deletion & duplication
  2. Whole-genome coverage (18,018 CNV & 148,450 SNP)
  3. Increased coverage density targeting 396 empirically selected regions relevant for prenatal loss ( 25markers/100kb)
  4. Allows for more precise medical management and genetic counselling
  5. Can detect a low level of mosaicism
  6. A minimum resolution of 500kb for loss/ gain and 5MB for LOH/AOH
  7. Detects MCC (Maternal Cell Contamination)
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