Hereditary Cancer Panel Test: Cancers Covered, Accuracy & Benefits

“Doctor, my mother had cancer, will I get it too?”

This is a very common question doctors get asked quite often, out of fear and sometimes from genuine desire to understand potential health risks. But, is it a valid question?

The answer is: yes, sometimes! Some cancers can run in the family. This is known as "Hereditary cancer," where a person can inherit faulty genes from their parents, increasing their risk of developing certain types of cancer. These genes may have been passed down through generations, just like we inherit certain facial features. Moreover, according to research, 5-10% of all cancers can be attributed to inherited gene mutations. Identifying these risks early can help individuals take proactive steps toward early detection, prevention, and better health management. ¹

In this blog, we will address all about hereditary cancer panel tests, types of cancers covered, accuracy of the hereditary cancer gene panel test and its benefits. 

What Is a Hereditary Cancer Panel Test?

A Hereditary Cancer Panel is a genetic test that aims to check genes associated with inherited cancer risk. These genes carry mutations that can be passed down from parents to children and increase the chances of developing some types of cancers. ²

Unlike a single-gene test, a cancer panel test checks multiple genes in a single analysis, making it efficient, comprehensive, and cost-effective.

What Cancers Are Covered in a Hereditary Cancer Panel Test?

A Hereditary Cancer Panel Test generally examines the genetic risks related to the following cancers: ^{3, 4}

• Ovarian Cancer 
• Colorectal Cancer 
• Breast Cancer
• Prostate Cancer 
• Pancreatic Cancer 
• Stomach/ Gastric Cancer 
• Endometrial Cancer
• Kidney Cancer 
• Melanoma 
• Thyroid Cancer 

Most commonly, the cancer panel test analyses genes like BRCA1, BRCA2, TP53, MLH1, MSH2, APC, PALB2, CHEK2. The number of genes analysed depends on the laboratory and the type of panel. ⁵

Who Should Consider a Hereditary Cancer Panel Test? ⁶

The following people can benefit the most from a Hereditary cancer gene panel test: 

• Have a history of family members suffering from cancer 
• Were diagnosed with cancer at a young age 
• Have multiple relatives with the same type of cancer 
• Have relatives with rare cancers like male breast cancer, medullary thyroid cancer, sarcomas, etc. 
• Have suffered from multiple primary cancers 
• You belong to a high-risk ethnic group like African Americans, American Indians, Asian Americans, etc. 
• Just want insights to prevent cancer  

How Accurate Is a Hereditary Cancer Panel Test?

Hereditary cancer gene panel tests are very accurate, mostly above 99% for detecting gene alterations precisely.⁷ However, the accuracy of the tests depends on the type of test, rare errors, or other factors, such as: 

1. Quality of the laboratory: A laboratory that uses next-generation sequencing (NGS) technology can read millions of DNA fragments simultaneously. This is a cutting-edge sequencing technology that provides high precision in detecting mutations across multiple genes.

2. Strict quality standards: An NABL and CAP- accredited lab adhere to established benchmarks for quality and reliability. Accredited laboratories are supposed to follow strict rules and validation processes to ensure accurate results. ⁸

3. Type of genetic mutation tested: A comprehensive Hereditary Gene Panel test can cover over 106 clinically relevant genes. These genes can help diagnose risks of all hereditary cancers. 
4. Quality of the sample: The quality of the sample is a critical part that defines accuracy in the hereditary panel test. A low-quality sample can lead to false negatives or a need for retests. 

Benefits of a Hereditary Cancer Panel Test

Some of the primary benefits of a complete hereditary panel test include: 

• Early detection of cancer risk
• Personalised cancer screening plans
• Preventive strategies (if needed)
• Change in lifestyle basis the results 
• Family risk assessment 
• Reduced anxiety and uncertainty 
• Improved treatment planning

Overall, a comprehensive gene panel test can help people to take control of their health, proactively. 

How the Test Works – Step-by-Step Process

The steps to get a hereditary cancer gene panel test include: 

• Counselling (pre-test): This is a preliminary discussion regarding risks and benefits
• Home sample collection to provide a blood or saliva sample 
• Laboratory analysis where experts check genetic mutations in the sample
• Report generation
• Post- test counselling to explain the results and discuss next steps 

Risks and Limitations of Hereditary Cancer Testing

Despite a lot of benefits, the hereditary gene panel tests have a few limitations as well, such as: 

• Anxiety 
• Uncertain results 
• Not all cancers are hereditary 
• Insurance implications 
• Limited certainty on prediction 
• A negative result does not eliminate cancer risk completely

Cost of Hereditary Cancer Panel Test

The cost of a hereditary cancer gene panel test in India can range from anywhere between ₹8000 to ₹30,000. The cost can depend on: 

• Number of genes tested
• Reputation of the laboratory 
• Inclusion of Counselling services 
• Testing method used 

Conclusion: 

A Hereditary Cancer Panel Test is a powerful way to unearth any inherited cancer possibilities. With the help of accurate results, professional counseling, and preventive care on time, you can make informed decisions about your health. 

For those looking for a reliable and all-inclusive option, the LifeCell Diagnostics Hereditary Cancer Gene Panel test offers exclusive screening of over 106 genes for cancer for both men and women at an affordable price. With the convenience of home sample collection and skilled phlebotomists, LifeCell Diagnostics conducts testing through its NABL-accredited laboratories, providing verified digital reports within 22 days.

Choosing a reliable and equipped provider like LifeCell Diagnostics ensures that you not just get accurate insights into your health but also guidance to work towards long-term health. 

FAQs

How do I know if cancer is hereditary?

Based on facts, cancer can be hereditary if a lot of family members have suffered from a similar cancer type. A Hereditary Cancer Gene Panel by LifeCell Diagnostics can help identify inherited cancer risks through a simple blood or saliva sample.

What is the Hereditary Cancer Gene Panel?

A Hereditary Cancer Gene Panel is a genetic test that detects most of the mutations (changes) in 106 genes linked to hereditary cancers.

How much does the hereditary cancer panel cost?

In India, a Hereditary Gene Panel test can cost anywhere between ₹8000 and ₹30,000, depending on the number of genes analysed and the laboratory performing the test. It’s important to choose a trusted diagnostics provider, such as LifeCell Diagnostics, that is NABL-accredited and trusted by 2,500+ doctors nationwide, to ensure reliable and accurate results.

How to get tested for hereditary cancer?

You can be tested for hereditary cancer at hospitals, leading diagnostic labs, or genetic clinics. LifeCell Diagnostics offers a Hereditary Cancer Gene Panel (ONCO) that tests more than 106 genes to assess hereditary cancer risk. Sample collection is performed by certified and trained paramedics, either at your home or at the lab, while following strict hygiene protocols.